G protein-coupled receptor 15 ligand (GPR15LG)

G protein-coupled receptor 15 ligand (GPR15LG, also known as C10orf99 or GPR15L) is a highly cationic, small, endogenous human peptide with multiple biological activities. It acts as a chemokine-like ligand for the orphan G protein-coupled receptor GPR15, mediating lymphocyte recruitment to epithelial barriers, including the colon and skin. GPR15LG is also notable for its direct antimicrobial activity against Gram-positive bacteria, mast cell activation via MRGPRs (contributing to pruritus), and potential tumor suppressor effects in colon cancer (possibly via growth inhibition and cell cycle arrest in cooperation with SUSD2). Structurally, GPR15LG is predicted to have two intramolecular disulfide bonds and shares similarities with CC family cytokines.

Other names

Protein GPR15LGC10orf99GPR15LUNQ1833/PRO3446AP-57Antimicrobial peptide-57CSBFRLLV1833FLJ21763Colon-derived SUSD2 binding factorProtein GPR15 ligandProtein GPR15LSecreted protein C10orf99

As a ligand, activates the G protein-coupled receptor GPR15 (agonist) Activates Mas-related G protein-coupled receptors (MRGPRs) to induce mast cell degranulation and pruritus (itch), independent of GPR15