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G protein-coupled receptor 153 (GPR153)
- Target
- GPR153
- Molecular classification
- G protein-coupled receptor, Receptor, Integral membrane protein, Class A rhodopsin superfamily
01
Overview
G protein-coupled receptor 153 (GPR153) is an orphan member of the Class A rhodopsin superfamily of G protein-coupled receptors, primarily expressed in the central nervous system, most notably in regions such as the thalamus, cerebellum, and arcuate nucleus[1][2][5][8]. Although its endogenous ligand and precise physiological role remain unidentified, available evidence indicates its involvement in neural signaling, regulation of food intake, decision making, and vascular responses, and it has been genetically linked to certain neuropsychiatric disorders including schizophrenia and autism[1][3][8]. GPR153 is evolutionarily related to GPR162 and, due to its CNS localization and disease associations, is being investigated as a potential therapeutic target[2][1][3].
- Other names
- Probable G protein-coupled receptor 153GPR153PGR1G protein-coupled receptor PGR1Putative G protein-coupled receptor 153Probable G-protein coupled receptor 153
02
Mechanism of action
As there are no drugs or ligands established for GPR153, mechanism of action for drugs is not defined.
03
Biological functions
Signal transductionRegulation of cAMP levelsProbable role in decision makingInvolved in food intake regulation in animal models
04
Disease associations
Neuropsychiatric disorders (e.g., schizophrenia, autism)Childhood-onset schizophreniaAcute salpingitisVascular damage response
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