G protein-coupled receptor 155 (GPR155)

G protein-coupled receptor 155 (GPR155) is an integral membrane protein encoded by the GPR155 gene in humans[4]. It is an atypical GPCR featuring a unique 17-transmembrane domain architecture, combining a transporter-like domain (10 TM) and a classical 7TM GPCR region, along with C-terminal DEP domains[2]. GPR155 binds cholesterol in lysosomal membranes, acting as a sensor to regulate mTORC1 signaling—promoting growth signaling when cholesterol is abundant[3][5]. In cancer (notably gastric cancer), reduced GPR155 expression is linked to increased metastasis and cell invasiveness; its mRNA level serves as a predictive biomarker for hematogenous spread[1][6]. Mutations or altered expression may be associated with autism spectrum disorder and other neurodevelopmental conditions[4]. There is no credible evidence for a distinct “divergent transcript” or for drug interactions with GPR155 to date.

Other names

LYCHOS proteinLYCHSintegral membrane protein GPR155

Drugs targeting GPR155 would theoretically modulate cholesterol sensing, mTORC1 activity, or related oncogenic signaling (e.g., p-ERK1/2, p-STAT1), but no specific drugs or actions are documented