Target intelligence / Profile preview

G protein-coupled receptor 160 (GPR160)

Target: GPR160
Molecular classification: G protein-coupled receptor, Receptor

Overview

Other names: GPR160Orphan G protein-coupled receptor 160

Mechanism of action

Inhibition of GPR160 signaling to reduce ERα protein levels and inhibit tumor growth in HR+ breast cancer.

Biological functions

Signal transductionCell proliferationRegulation of estrogen receptor alpha (ERα) signalingCell survival

Disease associations

CancerHormone receptor-positive breast cancerEndocrine resistance

Safety considerations

Potential off-target effects due to its orphan status and unknown endogenous ligandsImpact on normal physiological processes where GPR160 may be expressed

Biomarkers

GPR160 mRNA expressionGPR160 protein levelsPAM50 gene signature

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