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Target intelligence / Profile preview
G protein-coupled receptor 162 (GPR162)
- Target
- GPR162
- Molecular classification
- G protein-coupled receptor, Receptor, Integral membrane protein, Class A orphan GPCR
01
Overview
G protein-coupled receptor 162 (GPR162) is a probable G protein-coupled receptor mainly expressed in the human brain. It was identified by genomic analysis within a gene-rich region on chromosome 12p13. The gene encodes an orphan GPCR, meaning its endogenous ligand and specific physiological functions are currently unknown. Several transcript variants exist due to alternative splicing. Although GPR162 is part of the large class A (rhodopsin-like) GPCR family, there is no direct evidence of its involvement in a defined signaling pathway, biological process, or as a therapeutic drug target at present. Associations in genetic studies with disorders such as Fanconi anemia and abdominal obesity-metabolic syndrome 1 have been noted, but there are no mechanistic disease links or clinical targeting strategies validated for this receptor.
- Other names
- Probable G-protein coupled receptor 162GRCAA-2gene-rich cluster gene A proteingene rich clusterAGC12P006805GC12P006941GC12P006987GC12P006997GC12P007004GC12P007013GC12P007030GC12P007051GC12P007108GC12P007135
02
Biological functions
Signal transductionG protein-coupled receptor activityputative neurotransmission (suggested by brain expression)other (function not fully established)
03
Disease associations
Fanconi anemia (association)Abdominal obesity-metabolic syndrome 1 (association)Other (no established direct mechanistic disease link)
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