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Target intelligence / Profile preview
G protein-coupled receptor 17 (GPR17)
- Target
- GPR17
- Molecular classification
- G protein-coupled receptor
01
Overview
G protein-coupled receptor 17 is an intermediary GPCR involved in nucleotide/leukotriene signaling. It plays critical roles in CNS development/injury response—particularly regulating oligodendrocyte maturation/myelin repair—and represents an emerging therapeutic target for neurodegenerative diseases marked by demyelination or white matter loss.
02
Mechanism of action
Inhibition of GPR17 activity via binding of antagonists; Gi/o protein activation leading to inhibition of adenylyl cyclase; Gq protein activation.
03
Biological functions
Myelination regulationNeural injury sensingNeural repairRegulation of oligodendrocyte differentiationSignal transduction
04
Disease associations
Periventricular leukomalaciaEncephalomalaciaNeurodegenerative diseaseDemyelinating diseases
05
Interacting drugs
Montelukast
7 more in the full profile.
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