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Target intelligence / Profile preview
G protein-coupled receptor 183 (GPR183)
- Target
- GPR183
- Molecular classification
- G protein-coupled receptor, GPCR, Seven-transmembrane domain receptor
01
Overview
GPR183 (EBI2) is a chemotactic G protein-coupled receptor that plays a central role in the positioning, migration, and interaction of immune cells. It is highly expressed in immune system tissues and cells, including B cells, T cells, dendritic cells, monocytes, macrophages, and astrocytes. Activation of GPR183 by oxysterols, particularly 7α,25-dihydroxycholesterol (7α,25-OHC), guides immune cell movement within lymphoid tissues and contributes to effective adaptive immunity. Dysregulation of GPR183 signaling is implicated in viral infection-related inflammation and leukemia.
- Other names
- EBI2Epstein-Barr virus-induced G-protein coupled receptor 2
02
Mechanism of action
Ligand binding initiates Gi-alpha signaling, leading to downstream effects including MAPK/ERK pathway activation. Chemotaxis is a primary downstream effect.
03
Biological functions
Signal transductionImmune cell chemotaxisImmune cell localizationInflammation regulationB cell migrationT cell migrationDendritic cell migrationMonocyte migrationMacrophage migrationOsteoclast precursor migrationInsulin secretion regulation
04
Disease associations
Viral infectionInflammationLeukemiaImmunological disordersInflammatory disorders
05
Safety considerations
Activation during viral respiratory infections can exacerbate lung inflammation.Overexpression can enhance B cell egress from germinal centers, potentially contributing to leukemia pathogenesis.
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