G protein-coupled receptor 22 (GPR22)

G protein-coupled receptor 22 (GPR22) is an orphan class A rhodopsin-like GPCR primarily expressed in the heart and brain, as well as in chondrocytes under some pathological conditions. It possesses seven transmembrane helices and couples to inhibitory G proteins (Gi/Go) in transfected systems, resulting in adenylyl cyclase inhibition. GPR22 is implicated in the regulation of cardiac stress responses, cilia structure and function, and left-right axis development. It is part of a genetic locus associated with osteoarthritis susceptibility, although its direct role in disease remains debated. No endogenous or synthetic ligands for GPR22 have been identified, limiting therapeutic exploration. The receptor’s physiological and pathological significance warrants ongoing research, particularly regarding cardiac protection and ciliogenesis[2][3][4].

Other names

GPR22G protein-coupled receptor 22probable G protein-coupled receptor 22

For GPR22, transfected cell studies indicate constitutive coupling to Gi/Go proteins, leading to inhibition of adenylyl cyclase and decreased cAMP levels[2][4]. (No approved drugs, so therapeutic mechanism is hypothetical.)