G protein-coupled receptor 27 (GPR27)

G protein-coupled receptor 27 (GPR27) is an orphan Class A (Rhodopsin-like) G protein-coupled receptor highly conserved across vertebrates and predominantly expressed in the central nervous system, particularly in brain regions such as the hippocampal dentate gyrus and hypothalamus[2][4][7][8]. GPR27 is part of the "Super conserved receptor expressed in brain" (SREB) family, including SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173)[2][5]. No endogenous ligands have been identified, and its precise physiological and pathological roles remain undefined. Recent evidence links GPR27 to processes such as neural plasticity, neurodevelopmental disorders, and possibly insulin secretion, but functional studies are limited[4][8]. Two selective surrogate agonists have been discovered that activate β-arrestin recruitment, but not classical G protein pathways[3]. No established drugs target GPR27, and further research is needed to clarify its disease relevance and therapeutic utility.

Other names

Super conserved receptor expressed in brain 1SREB1Probable G-protein coupled receptor 27Orphan GPCRGPR27_HUMANQ9NS67

For surrogate agonists: β-arrestin 2 recruitment (no evidenced G protein activation for these compounds)[3]