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Target intelligence / Profile preview
G-protein Coupled Receptor 35 (GPR35)
- Target
- GPR35
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Orphan Receptor
01
Overview
GPR35 is an orphan GPCR with high expression in immune/gastrointestinal tissues. It modulates inflammation through complex mechanisms that can be either pro-or anti-inflammatory based on cellular context. Its involvement extends into cardiovascular regulation and cancer biology—making it a promising therapeutic target despite challenges related to ligand specificity/species selectivity among tool compounds currently available for research use.
02
Mechanism of action
GPR35 activation induces conformational change leading to activation of associated heterotrimeric G proteins. Downstream signaling influences immune cell activation/chemotaxis/cytokine production or suppression depending on cellular context. Modulates angiogenesis within tumor microenvironments.
03
Biological functions
Signal transductionImmune modulationVascular tone regulationAngiogenesisNeutrophil recruitmentEndothelial function
04
Disease associations
Cancer progressionInflammatory diseasesCardiovascular dysfunctionBrachydactyly mental retardation syndromeChromosomal disorders
05
Safety considerations
Ligand specificity challengesSpecies selectivity of tool compoundsDual pro-/anti-inflammatory roles requiring careful consideration for therapeutic intervention
06
Interacting drugs
Zaprinast
3 more in the full profile.
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