G protein-coupled receptor 37-like 1 (GPR37L1)

G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan G protein-coupled receptor highly expressed in glial cells within the central and peripheral nervous systems, especially in cerebellar astrocytes (Bergmann glia) and satellite glial cells. It plays a role in signal transduction by coupling to the G(s) protein and regulates important glial functions, including potassium channel activity and synaptic signaling. GPR37L1 has been implicated in the modulation of the sonic hedgehog (Shh) pathway during cerebellar development and is involved in neuroprotection, pain regulation, and cardiovascular homeostasis. The receptor can be activated by the lipid mediator maresin 1, which enhances neuroprotective signaling, and has been proposed to interact with prosaposin, though functional activity is debated. Genetic variants in GPR37L1 have been associated with susceptibility to chronic pain and epilepsy. Loss or dysfunction of GPR37L1, as seen in transgenic mice, leads to impaired neuropathic pain resolution and altered cerebellar development[1][2][3][4][5].

Other names

Endothelin B receptor-like protein 2ET(B)R-LP-2ETBR-LP-2ETBRLP2Prosaposin receptor GPR37L1G-protein coupled receptor 37-like 1Endothelin type b receptor-like protein 2

Activation by maresin 1 to regulate potassium influx via Kir4.1/Kir3.1; Constitutive activity through Gs signaling; Activation by prosaposin (uncertain and debated; studies report mixed findings on activity)