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Target intelligence / Profile preview
G-protein Coupled Receptor 44 (GPR44)
- Target
- GPR44
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
G-protein coupled receptor 44 (GPR44) is a member of the GPCR family, acting as a receptor for prostaglandin D2 (PGD2). It plays a significant role in mediating chemotactic responses, particularly in eosinophils, basophils, and Th2 cells, making it relevant to inflammatory processes like asthma and allergic diseases. GPR44 is also expressed in human pancreatic islets, but not in exocrine pancreas tissue making it a potential biomarker for pancreatic beta cell mass assessment.
- Other names
- CD294Chemoattractant Receptor-Homologous Molecule Expressed on Th2 cellsProstaglandin D2 receptor 2DP2
02
Mechanism of action
Selective antagonist
03
Biological functions
Signal transductionChemotaxisImmune regulationReceptor for prostaglandin D2 (PGD2)
04
Disease associations
AsthmaAllergic disordersInflammationDiabetes
05
Interacting drugs
TM30089
06
Biomarkers
Pancreatic beta cell mass assessment
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