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G protein-coupled receptor 6 (None)

Target: None
Molecular classification: GPCR Class A, Orphan Receptor

Overview

G protein-coupled receptor 6 (GPR6) is an orphan GPCR belonging to the Class A family. It exhibits constitutive activity and can be further activated by sphingosine-1-phosphate. GPR6 upregulates cAMP levels and promotes neurite outgrowth, suggesting a role in neural development and function. It is considered a potential drug target due to its involvement in cAMP signaling and neurological function.

Mechanism of action

G protein activation, cAMP modulation

Biological functions

Signal transductionUpregulates cAMP levelsPromotes neurite outgrowth

Disease associations

Neurodevelopmental disordersNeurological disorders

Safety considerations

Limited understanding of endogenous ligand functionPotential for off-target effects due to GPCR promiscuity

Interacting drugs

Sphingosine-1-phosphate

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