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Target intelligence / Profile preview
G protein-coupled receptor 68 (GPR68)
- Target
- GPR68
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Rhodopsin-like GPCR
01
Overview
G protein-coupled receptor 68 (GPR68), also known as Ovarian cancer G-protein coupled receptor 1 (OGR1) or Sphingosylphosphorylcholine receptor, is a proton-sensing receptor that responds to changes in extracellular pH. It is involved in various biological activities, including inflammation, cardiovascular physiology, and tumor microenvironment modulation. GPR68 is expressed widely across tissues and is considered a potential drug target for inflammatory diseases and cancers characterized by acidic microenvironments.
- Other names
- OGR1Ovarian cancer G-protein coupled receptor 1Sphingosylphosphorylcholine receptor
02
Mechanism of action
Acts as a proton-sensing receptor, responding to changes in extracellular pH and activating downstream signaling pathways, including cAMP/PKA/CREB signaling. May also be regulated by certain lipid molecules.
03
Biological functions
Signal transductionProton sensingRegulation of inflammatory responsesRegulation of cell migrationCardiovascular physiology
04
Disease associations
OsteoarthritisInflammationCancerTumor microenvironment modulationCardiovascular disease
05
Safety considerations
Potential for off-target effects due to broad tissue expressionComplexity of downstream signaling pathways may lead to unpredictable effectsAcidosis-driven activation
06
Biomarkers
GPR68 expression in cartilage as an indicator of osteoarthritis progression
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