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Target intelligence / Profile preview
G protein-coupled receptor 75 (GPR75)
- Target
- GPR75
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR
01
Overview
G protein-coupled receptor 75 (GPR75) is a member of the GPCR family involved in various physiological processes. It is implicated in obesity, metabolic syndrome, cardiovascular diseases, and cancer. Ligands include 20-HETE and CCL5, activating pathways like PI3K/Akt and RAS/MAPK.
- Other names
- GPRchr2WI31133G protein-coupled receptor 75
02
Mechanism of action
Modulation of GPR75 signaling through agonism or antagonism.
03
Biological functions
Signal transductionVascular tone regulationEnergy metabolismCell proliferationCell migrationEndothelial dysfunctionInflammation regulation
04
Disease associations
ObesityMetabolic syndromeHypertensionCardiovascular diseaseCancer
05
Safety considerations
Potential for off-target effects due to GPCR family similarities.Long-term effects of GPR75 modulation need further investigation.
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