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G protein-coupled receptor 84 (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR, Class A Rhodopsin-like GPCR, Receptor
01
Overview
GPR84 is a G protein-coupled receptor that acts as a pro-inflammatory receptor in immune cells and a sensor for medium-chain free fatty acids. It is highly expressed in immune-related tissues and cells, and its expression is upregulated in inflammatory states and metabolic disorders. GPR84 plays roles linking innate immunity with metabolic disease pathogenesis due to its dual function sensing dietary fatty acids/nutrients while regulating inflammatory processes.
- Other names
- GPR84EX33Inflammation-related GPCR EX33
02
Mechanism of action
Modulation of AKT, ERK, and NF-kappa-B signaling pathways; regulation of cytokine production; modulation of neutrophil functions; regulation of inflammasome activation
03
Biological functions
Signal transductionImmune responseChemotaxisNutrient sensingFatty acid sensingInflammation
04
Disease associations
InflammationMetabolic disordersDiabetesObesityNeuroinflammationInfection
05
Safety considerations
Potential for off-target effects due to broad expression in immune and metabolic tissues.Pro-inflammatory role requires careful consideration in chronic inflammatory conditions.
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