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Target intelligence / Profile preview
G protein-coupled receptor class 5 member D (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR, Class C GPCR, Orphan GPCR, Receptor
01
Overview
G protein-coupled receptor class 5 member D (GPRC5D) is a class C orphan GPCR predominantly expressed in multiple myeloma cells and hard keratinized tissues like hair and nails. Its limited expression in most normal human tissues makes it an attractive therapeutic target for multiple myeloma. Several immunotherapies, including bispecific antibodies and CAR T-cell therapies, are being developed against GPRC5D. Overexpression in bone marrow correlates with poor prognosis for MM patients.
- Other names
- G protein-coupled receptor, class C, group 5, member DG protein-coupled receptor class C group 5 member D
02
Mechanism of action
Redirects T cells to kill GPRC5D+ MM cells by binding both CD3 on T cells & GPRC5D; Binds ECLs/TM domains of dimeric GPRC5D; Engineered T cells targeting surface-expressed GPRC5D
03
Biological functions
Signal transductionKeratin expressionHair follicle developmentNail development
04
Disease associations
CancerMultiple Myeloma
05
Safety considerations
Off-tumor effects due to low expression in some normal tissuesCytokine release syndrome (CRS) with bispecific antibodies and CAR-T cell therapiesNeurotoxicity
06
Interacting drugs
JNJ-64407564
2 more in the full profile.
07
Biomarkers
GPRC5D expression in bone marrowGPRC5D surface expression
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