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Target intelligence / Profile preview
G-protein coupled receptor class C group 5 member C (GPRC5C)
- Target
- GPRC5C
- Molecular classification
- G protein-coupled receptor, Receptor, Orphan receptor, Type 3 G protein-coupled receptor subfamily
01
Overview
G-protein coupled receptor class C group 5 member C (GPRC5C) is a type 3 G protein-coupled receptor characterized by a signature 7-transmembrane domain motif and a short N-terminal domain. Its gene is retinoic acid-inducible. While its precise physiological ligand and function remain unknown, it may mediate retinoic acid effects on G protein signal transduction and appears to play a role in cell signaling, particularly in osteoblast differentiation and bone-related pathways, and possibly in cancers and cystinuria. It is expressed in several peripheral tissues as well as the brain, and evidence suggests that it may interact with hyaluronic acid or saccharides. Current research considers it an orphan receptor with therapeutic potential for bone and cancer disorders, though no drugs targeting GPRC5C are established yet[1][3][5][7][8].
- Other names
- Retinoic acid-induced gene 3 proteinRAIG3PSEC0087RAIG-3orphan G-protein coupled receptorretinoic acid responsive gene proteinGPRC5C
02
Mechanism of action
Not established; hypothesized mediation of retinoic acid-induced regulation and possible interaction with carbohydrates (e.g., hyaluronic acid)
03
Biological functions
Signal transductionPotential mediator of retinoic acid effects on G protein signalingRegulation of osteoblast differentiationPossible involvement in Wnt signaling pathway
04
Disease associations
Cancer (expression in multiple carcinoma and cancer types, e.g., kidney, breast, liver, brain)Bone-related disorders (osteopenia, osteoblast differentiation)CystinuriaPotential roles in other diseases (expression across multiple tissues and developmental regulation)
05
Safety considerations
Unknown; receptor is understudied and not yet therapeutically targeted. No notable safety concerns documented
06
Interacting drugs
None known as of current research; ligands and antagonists remain to be developed
07
Biomarkers
mRNA expression may serve as a biomarker for osteoblast differentiation and bone-anabolic responses
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