Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
G protein-coupled receptor class C group 5 member D (GPRC5D)
- Target
- GPRC5D
- Molecular classification
- G protein-coupled receptor, GPCR, Class C GPCR, Orphan receptor, Receptor
01
Overview
GPRC5D is an orphan G protein-coupled receptor (GPCR) belonging to the class C family. It is predominantly expressed in hard keratinized tissues like hair and nails, and highly expressed in multiple myeloma cells, but shows low expression in most other normal human tissues. While its exact biological function remains unclear, it is implicated in hair and nail development. GPRC5D is a therapeutic target for multiple myeloma, with immunotherapies like CAR T-cell therapy and bispecific antibodies (e.g., talquetamab) showing promising efficacy due to its restricted expression profile, which reduces off-target effects. Structural studies reveal GPRC5D forms dimers, influencing drug binding characteristics.
- Other names
- G protein-coupled receptor family C group 5 member DG-protein coupled receptor family C group 5 member DGPCR, family C, group 5, member DHGNC:13578
02
Mechanism of action
Bispecific antibody that binds to CD3 on T cells and GPRC5D on tumor cells, leading to T cell-mediated tumor cell killing.
03
Biological functions
Signal transductionGPCR signalingHair follicle developmentNail development
04
Disease associations
CancerMultiple myeloma
05
Safety considerations
Cytokine release syndromeNeurological toxicitiesOff-target effects on keratinized tissues (potential)Limited expression in normal tissues may reduce off-target toxicity risks
06
Interacting drugs
Talquetamab
07
Biomarkers
GPRC5D expression in multiple myeloma cells
Beyond the preview
Go deeper on G protein-coupled receptor class C group 5 member D (GPRC5D).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on G protein-coupled receptor class C group 5 member D (GPRC5D).