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G protein-regulated inducer of neurite outgrowth 2 (GPRIN2)

Target: GPRIN2
Molecular classification: Other (developmental protein)

Overview

G protein-regulated inducer of neurite outgrowth 2 (GPRIN2) is a protein-coding gene expressed predominantly in the brain and nervous system, where it is thought to promote neurite outgrowth and the development of neuronal projections. It is active at the plasma membrane and is associated through genetic studies with bladder squamous cell carcinoma and Glass syndrome, but its direct role as a therapeutic target has not been established. GPRIN2 is part of the developmental protein class rather than classic receptor, enzyme, or transporter families.

Other names: GPRIN2GRIN2KIAA0514MGC15171

Biological functions

Neurite outgrowthNeuron projection developmentNervous system development

Disease associations

Cancer (notably bladder squamous cell carcinoma and possibly Glass syndrome, based on genetic association, but functional links to disease mechanisms are unclear)

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