Target intelligence / Profile preview

G protein subunit alpha s (Gαs)

Target: Gαs
Molecular classification: G protein subunit

Overview

Gαs is a subunit of heterotrimeric G proteins, primarily involved in the stimulatory regulation of adenylyl cyclase activity. This results in increased intracellular cAMP levels, which play a crucial role in various signaling pathways affecting heart rate, smooth muscle contraction, and metabolism.

Other names: Stimulatory G protein alpha subunit

Mechanism of action

Activation of adenylyl cyclase leading to increased cAMP levels

Biological functions

Signal transductionactivation of adenylyl cyclase

Disease associations

Cardiovascular diseaseneurodegenerative diseases

Safety considerations

Overactivation of Gαs pathways can lead to adverse cardiovascular effects

Interacting drugs

beta-agonists

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