G protein subunit beta 5 (GNB5)

G protein subunit beta 5 (GNB5) is a regulatory protein that forms part of the heterotrimeric guanine nucleotide-binding (G) protein complex, functioning primarily to mediate and regulate signal transduction initiated by G protein-coupled receptors (GPCRs). It modulates signaling by regulating the GTPase activities of regulators of G protein signaling (RGS) proteins, especially RGS7 and RGS9, which are critical for the termination of G protein signaling in the nervous system, mood and cognition, and heart rate control. Mutations in GNB5 are associated with neurodevelopmental syndromes presenting intellectual disability, developmental delay, and cardiac arrhythmias. No direct pharmacological agents or drugs target GNB5 as of the provided data.

Other names

G protein subunit beta 5Guanine nucleotide-binding protein subunit beta-5Transducin beta chain 5GB5Gbeta5G protein beta 5G protein subunit β 5guanine nucleotide binding protein (G protein), beta 5guanine nucleotide binding protein (G protein), β 5HG2EIDDCALADCILDMLS1LDMLS2guan nuc b5GBSflr

Accelerates GTP hydrolysis on Gα subunits via enhancement of regulator of G protein signaling (RGS) protein activity, promoting inactivation of G protein signaling