G protein subunit gamma-10 (GNG10)

G protein subunit gamma-10 (GNG10) is a component of the heterotrimeric G protein complex together with alpha and beta subunits. These complexes act downstream of G protein-coupled receptors (GPCRs) to transmit extracellular signals into intracellular responses. The gamma subunit, together with the beta subunit, forms a stable beta-gamma dimer that modulates various signaling effectors, including ion channels, adenylyl cyclases, and phospholipase C. GNG10 is ubiquitously expressed, and disruption of its expression or function can lead to distinct cellular and disease phenotypes, including cancer progression and neurodevelopmental disorders. While not a direct therapeutic target, it plays critical roles in multiple tissues by regulating the spatial and temporal specificity of GPCR signaling.

Other names

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10GNGT10Guanine nucleotide binding protein (G protein), gamma 10Guanine nucleotide binding protein 10

GNG10 is not a direct drug target; drugs modulating GPCR signaling may indirectly influence GNG10's function as part of G protein complexes