G protein subunit gamma 13 (GNG13)

G protein subunit gamma 13 (GNG13) is a gamma subunit of heterotrimeric G proteins involved in modulating and transducing signals from G protein-coupled receptors (GPCRs). It is specifically expressed in taste, retinal, and neuronal tissues, and plays a crucial role in taste transduction and neuronal signaling. The beta and gamma chains are necessary for GTPase enzymatic function, GDP-GTP exchange, and interaction with downstream effectors. Currently, there are no known direct drugs that target GNG13, and it is not considered a therapeutic target itself, but rather a signaling component within broader GPCR pathways[1][3][4][5][7][8].

Other names

Gγ13G(gamma)13G gamma subunitclone:h2-35HG3Jh2-35guanine nucleotide-binding protein (G protein), gamma 13guanine nucleotide binding protein 13, gammaheterotrimeric guanine nucleotide-binding protein 3J1500031D04RikLOC682159