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Target intelligence / Profile preview
G-quadruplex DNA Structure (G4 DNA)
- Target
- G4 DNA
- Molecular classification
- Nucleic acid structure, DNA secondary structure
01
Overview
G-quadruplexes (G4s) are non-canonical, four-stranded secondary structures formed by guanine-rich sequences in nucleic acids. They are built around stacks of guanine tetrads, stabilized by monovalent cations, and exhibit diverse topologies. G4s are involved in key genomic processes and are considered promising molecular targets for drug discovery, particularly in cancer therapy. Several small-molecule ligands have been developed to selectively bind/stabilize G4s.
- Other names
- G-quadruplexesG4sG-tetradsG-quartets
02
Mechanism of action
Stabilization of G-quadruplex structures
03
Biological functions
Transcriptional regulationReplicationTelomere maintenanceGenome stabilityEpigenetic regulation
04
Disease associations
CancerAgingNeurological disordersGenome instability
05
Safety considerations
Ligand selectivity due to structural similarities among different quadruplexesGenomic instability if G4 stabilization is not properly regulated
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