Target intelligence / Profile preview

G1 to S Phase Transition 1 (GSPT1)

Target: GSPT1
Molecular classification: GTP-binding protein, Translation termination factor, Cell cycle regulator

Overview

G1 to S phase transition 1 (GSPT1), also known as eukaryotic peptide chain release factor GTP-binding subunit ERF3A, is a protein encoded by the *GSPT1* gene in humans. It plays a central role in both mRNA translation and regulation of the cell cycle, particularly at the G1/S checkpoint. It also interacts with ASK1 and regulates apoptosis.

Other names: ERF3AETF3AEukaryotic peptide chain release factor subunit 3aGST1

Biological functions

mRNA translation terminationCell cycle regulationApoptosis regulationCheckpoint control

Disease associations

Cancer

Safety considerations

Aberrant expression or function may contribute to tumor development.

Beyond the preview

Go deeper on G1 to S Phase Transition 1 (GSPT1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on G1 to S Phase Transition 1 (GSPT1).

Explore the full profile