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Target intelligence / Profile preview
G1 to S phase transition 1 protein (GSPT1)
- Target
- GSPT1
- Molecular classification
- Translation termination factor, GTP-binding protein
01
Overview
GSPT1 is a translation termination factor that plays a central role in mRNA translation by facilitating the termination phase of protein synthesis. Beyond translation, it regulates the G1/S checkpoint of the cell cycle and contributes to tumorigenesis by promoting cell cycle progression. It has been linked to poor prognosis in cancers like colon and liver cancer, making it a target for anticancer drug development.
- Other names
- ETF3AGST1eRF3aERF3A551G9.2
02
Mechanism of action
Inhibition of GSPT1 leads to reduced proliferation and increased apoptosis in tumor cells, impacting cell cycle progression.
03
Biological functions
Translation terminationCell cycle regulationCell proliferationCell survival
04
Disease associations
CancerColon cancerLiver cancer
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