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G2 Phase of the Cell Cycle (G2 Phase)

Target: G2 Phase
Molecular classification: Cell cycle phase

Overview

The G2 phase is a period in the cell cycle occurring after DNA replication (S phase) and before mitosis (M phase). It is characterized by continued cell growth and protein synthesis. A crucial G2/M checkpoint ensures complete DNA replication and repair of any DNA damage before the cell commits to mitosis, safeguarding genomic integrity. Key regulators include cyclin-dependent kinases (CDKs), cyclins, and checkpoint proteins.

Other names: Post-DNA synthesis/pre-mitosis phaseGap 2 phase

Biological functions

Cell cycleDNA damage repairCell growthProtein synthesisPreparation for mitosisCheckpoint control

Disease associations

Cancer (deregulation of cell cycle control)

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