GABA-A Receptor Subunit Alpha 1 (GABRA1)

The GABA-A receptor subunit alpha-1 (GABRA1) is a protein encoded by the GABRA1 gene. It is a subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system. Activation of the receptor by GABA allows chloride ions to flow into neurons, hyperpolarizing the neuron membrane and inhibiting action potential firing. The alpha 1 subunit is crucial for the sedative/hypnotic effects of benzodiazepines and is a primary target of Z-drugs for sleep aids. Dysfunctions or mutations in GABRA1 have been linked to epilepsy syndromes.

Other names

GABA A Receptor Alpha1 SubunitGABA(A) Receptor Alpha 1Gamma-aminobutyric acid receptor subunit alpha-1

Binding to the GABA-A receptor, enhancing GABA-mediated chloride ion influx, leading to neuronal hyperpolarization and inhibition of neuronal firing.