GABA type A receptor-associated protein-like 3 (GABARAPL3)

GABA type A receptor-associated protein-like 3 is a member of the GABARAP/Atg8 protein family, related to autophagy regulatory proteins and intracellular membrane trafficking factors[2][4][6]. Like its relatives, GABARAPL3 contains a ubiquitin-like domain and is predicted to enable binding to GABA receptors, phosphatidylethanolamine, and ubiquitin protein ligases[4][6]. It is primarily involved in the process of autophagosome formation, cargo sequestration, and possibly the trafficking of membrane proteins such as neurotransmitter receptors. Its biological functions are largely inferred from homology with better-studied family members, specifically GABARAP and GABARAPL1, which participate in autophagy and in stabilizing and trafficking GABA type A receptors at neuronal synapses. Direct research on GABARAPL3 is limited, and more work is needed to clarify its unique cellular roles and disease associations.\n\nIf structured data or direct experimental literature about GABARAPL3 is needed, it should be noted that most knowledge is extrapolated from similar family members and predicted protein functions, not direct large-scale experiments on GABARAPL3 itself.

Other names

GABARAPL3Gamma-aminobutyric acid receptor-associated protein-like 3

Not directly established for GABARAPL3. By analogy to GABARAP/GABARAPL1, potential mechanisms include modulation of autophagosome formation or trafficking of GABA receptor complexes.