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Target intelligence / Profile preview
GABA~A~ receptor (GABA~A~R)
- Target
- GABA~A~R
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor
01
Overview
The GABA~A~ receptor is an ionotropic receptor and ligand-gated ion channel that plays a crucial role in inhibitory neurotransmission in the central nervous system. It is composed of various subunits (α, β, γ, δ, ε, θ, π, ρ) that form a heteropentameric structure. The receptor is selectively permeable to chloride ions and is modulated by a variety of drugs, including benzodiazepines and ethanol, which act at allosteric binding sites to enhance GABA's inhibitory effects[1][4][5].
- Other names
- GABA~A~ receptorGABA~A~R
02
Mechanism of action
Allosteric modulation, Potentiation of GABA-mediated chloride influx, Inhibition of neuronal excitability
03
Biological functions
Signal transductionInhibition of neuronal activityRegulation of chloride ion flow
04
Disease associations
Neurodegenerative diseaseEpilepsyAnxiety disordersSleep disorders
05
Safety considerations
DependenceWithdrawal symptomsSedationRespiratory depression
06
Interacting drugs
Benzodiazepines
3 more in the full profile.
07
Biomarkers
None specifically identified for patient selection or efficacy monitoring
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