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Target intelligence / Profile preview
Gadolinium (Gd)
- Target
- Gd
- Molecular classification
- Element, Lanthanide, Rare-earth metal
01
Overview
Gadolinium is a rare-earth metal used primarily as a component of intravenous contrast agents for MRI scans. It exhibits strong paramagnetic properties at body temperature. Free gadolinium ions are toxic, necessitating chelation within GBCAs to reduce toxicity. Retention risks exist, especially in patients with impaired renal function.
02
Mechanism of action
Paramagnetic enhancement of MRI signals
03
Biological functions
MRI contrast enhancementNeutron capture
04
Safety considerations
Toxicity of free gadolinium ionsGadolinium retention in patients with renal dysfunctionPotential skin changes and organ complications from GBCA exposure
05
Interacting drugs
Gadolinium-based contrast agents (GBCAs)
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