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Target intelligence / Profile preview
Gag-p41 Antigen
- Molecular classification
- Viral protein, Structural protein
01
Overview
The Gag-p41 antigen is a cleavage product of the HIV-1 Gag polyprotein, comprised of the capsid protein (p24) and spacer peptide 1 (SP1). It is essential for virus assembly, maturation, and genome packaging. It is also a key target for maturation inhibitors and a common antigen used in HIV vaccine development due to its ability to elicit strong T cell responses. Mutations in the CA-SP1 region can lead to drug resistance.
- Other names
- HIV-1 Gag-p41p41 GagCA-SP1Capsid-SP1Gag polyprotein fragment
02
Mechanism of action
Maturation inhibitors block cleavage of the Gag polyprotein at the CA-SP1 junction.
03
Biological functions
Viral assemblyVirion maturationGenome packagingImmune response elicitation
04
Disease associations
HIV-1 infectionAIDS
05
Safety considerations
Drug resistance development
06
Interacting drugs
Bevirimat
1 more in the full profile.
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