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Target intelligence / Profile preview
Gag Protein of Human Immunodeficiency Virus Type 1 (Gag)
- Target
- Gag
- Molecular classification
- Polyprotein, Viral protein, Structural protein
01
Overview
The Gag protein of HIV-1 is a polyprotein essential for the late phase of the viral life cycle, including assembly, budding, and maturation. It drives auto-assembly at the plasma membrane, orchestrates encapsidation of genomic RNA, interacts with host cell proteins, and is cleaved by HIV protease into mature structural proteins. Gag is a promising target for future antiretroviral therapies aimed at disrupting viral assembly and budding.
- Other names
- Group-specific antigenPr55^GagMA (Matrix/p17)CA (Capsid/p24)NC (Nucleocapsid/p7)p6
02
Mechanism of action
N/A
03
Biological functions
Viral assemblyViral buddingViral maturationGenome packagingMembrane bindingMultimerizationHost factor recruitment
04
Disease associations
HIV-1 infectionAIDS
05
Safety considerations
High mutation rate leading to drug resistancePotential for off-target effects due to interactions with host cell proteins
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