Galactose-3-O-sulfotransferase 3 (GAL3ST3)

Galactose-3-O-sulfotransferase 3 is an enzyme encoded by the GAL3ST3 gene in humans, responsible for transferring a sulfate group to the 3' position of galactose within N-glycans and core2-branched O-glycans[1][2][7]. This modification alters the physical and biological properties of glycoproteins and glycolipids, influencing cellular processes such as cell-cell recognition and signal transduction[1][2]. GAL3ST3 belongs to the family of sulfotransferases, and while its specific physiological and pathological roles in human disease are not well defined in current literature, sulfotransferase-mediated sulfonation is known to impact immune function, development, and potentially disease progression through modification of glycan structures on cell surfaces and secreted molecules[1][5][7].

Other names

GAL3ST3Galactose-3-O-sulfotransferase 3Gal3ST-3Beta-galactose-3-O-sulfotransferase 3Gal-beta-1,3-GalNAc 3'-sulfotransferase 3galactose 3'-sulfotransferasegalbeta1-3GalNAc 3'-sulfotransferase 3GAL3ST2