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Target intelligence / Profile preview
Galectin-1 (Gal-1)
- Target
- Gal-1
- Molecular classification
- Lectin, β-galactoside-binding protein
01
Overview
Galectin-1 is a member of the galectin family, which are β-galactoside-binding proteins involved in modulating cell-cell and cell-matrix interactions. It plays a crucial role in immune regulation, cancer progression, and various inflammatory conditions. It can be found intracellularly and extracellularly, influencing diverse biological processes through its carbohydrate recognition domain (CRD).
- Other names
- LGALS1Lectin, galactoside-binding, soluble 1
02
Mechanism of action
Modulation of immune cell activity and cell-matrix interactions through binding to β-galactosides.
03
Biological functions
Immune regulationT-cell apoptosisImmunosuppressionCell proliferationCell differentiationCell-matrix interactionsApoptosis
04
Disease associations
CancerAutoimmune diseasesInflammationInfectionNeurodegeneration
05
Safety considerations
Potential for immunosuppressionComplex role in cancer progression; targeting requires careful consideration
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