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Target intelligence / Profile preview
Galectin-3 (Gal-3)
- Target
- Gal-3
- Molecular classification
- Lectin, β-galactoside-binding lectin
01
Overview
Galectin-3 is a β-galactoside-binding lectin involved in diverse cellular processes including cell adhesion, growth, apoptosis, inflammation, fibrosis, and host defense. It is implicated in numerous diseases, including cardiovascular disease, fibrotic diseases, cancer, and metabolic disorders. It serves as a biomarker and a potential therapeutic target.
- Other names
- Mac-2L-29L-31L-34Immunoglobulin E-binding protein (IgE-BP)CBP35CBP30
02
Mechanism of action
Drugs targeting galectin-3 inhibit its glycan-binding activity or downstream signaling pathways involved in scarring/tumorigenesis.
03
Biological functions
Cell adhesionCell growth & proliferationApoptosis regulationInflammation & immune responseFibrosisHost defenseAngiogenesisRegulation of pre-mRNA splicingGene transcription
04
Disease associations
Cardiovascular diseaseFibrotic diseasesCancerMetabolic disordersRenal diseaseNeurodegenerative disordersAutoimmune/inflammatory diseases
05
Safety considerations
Premature senescence phenotypes in knockout studies
06
Biomarkers
Diagnostic/prognostic biomarker for heart failureDiagnostic/prognostic biomarker for fibrosisDiagnostic/prognostic biomarker for cancerDiagnostic/prognostic biomarker for kidney disease
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