Galyfilcon A

Galyfilcon A is a silicone hydrogel polymer used as the base material for Acuvue Advance contact lenses, developed by Johnson & Johnson Vision Care. It represents a significant advancement in biomaterials by combining high oxygen permeability with a high water content (47%), facilitating better corneal health compared to traditional pHEMA-based hydrogels (Source: Eye & Contact Lens, 2003, PMID: 12544914). The material surface is characterized by the "Hydraclear" technology, which involves the internal incorporation of a wetting agent, polyvinyl pyrrolidone (PVP), to maintain surface moisture and improve wearer comfort without the need for surface treatments (Source: Optometry and Vision Science, 2007, PMID: 17435512). While Galyfilcon A is not a biological target like a receptor or enzyme, its surface properties are critical for its interaction with the tear film and the ocular microbiota. The material is primarily indicated for the correction of refractive errors such as myopia and hyperopia, but its surface can also act as a reservoir for topically applied ophthalmic drugs, potentially altering their pharmacokinetics or causing lens discoloration (Source: Clinical Ophthalmology, 2010, PMID: 20463801). Over time, the surface may accumulate proteins and lipids, which can lead to inflammatory responses or reduced comfort, and the material has largely been superseded by newer generations of silicone hydrogels like Senofilcon A.

Other names

Acuvue AdvanceAcuvue Advance with HydraclearSilicone hydrogel materialHydraclear lens material

Physical refraction of light for vision correction and passive oxygen diffusion to support corneal metabolism.