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Target intelligence / Profile preview
Gametocyte Surface Protein PFS230 (Pfs230)
- Target
- Pfs230
- Molecular classification
- Surface protein, PGSH family protein
01
Overview
Pfs230 is a large, cysteine-rich surface protein expressed by the malaria parasite *Plasmodium falciparum* during its sexual stages. It is a leading target for malaria transmission-blocking vaccines (TBVs) due to its essential role in parasite development and transmission from humans to mosquitoes. It is required for male/female gamete fusion, essential for male gamete exflagellation, and involved in interaction with host erythrocytes; parasites lacking Pfs230 cannot bind red blood cells or develop into oocysts within mosquitoes, thus blocking transmission. Antibodies against specific regions—especially domain 1—can block parasite transmission.
- Other names
- PFS230pfs230
02
Mechanism of action
Antibody-mediated blocking of gamete fusion and parasite development in mosquitoes
03
Biological functions
Gamete fusionExflagellationErythrocyte bindingTransmission-blocking target
04
Disease associations
MalariaInfection
05
Safety considerations
Potential for immune evasion by the parasiteNeed for broad strain coverage in vaccine developmentImmunogenicity of recombinant fragments
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