Gamma-1-syntrophin (SNTG1)

Gamma-1-syntrophin is a cytoplasmic peripheral membrane adapter protein encoded by the human SNTG1 gene on chromosome 8. It contains two pleckstrin homology (PH) domains, a PDZ domain, and a C-terminal domain that can bind dystrophin. SNTG1 is expressed predominantly in the brain and is important for organizing the subcellular localization of various proteins, often by linking receptors to cellular structural frameworks such as the actin cytoskeleton and dystrophin glycoprotein complex. Additionally, it plays a role in regulating the positioning and inactivation of molecules like diacylglycerol kinase-zeta following receptor activation and is involved in trafficking gamma-enolase to the plasma membrane to enhance neurotrophic activity. Genetic variants and abnormalities in SNTG1 have been associated with several neurological and autoimmune diseases, but SNTG1 is not presently considered a direct therapeutic target such as a receptor, enzyme, or transporter[1][2][3][7][8].

Other names

G1SYNSYN4syntrophin gamma 1syntrophin-4gamma1-syntrophinsyntrophin 4