Gamma-2-syntrophin (SNTG2)

Gamma-2-syntrophin (SNTG2) is a cytoplasmic peripheral membrane adaptor protein and member of the syntrophin family, encoded by the SNTG2 gene on chromosome 2[1][2][4][6][7]. It interacts with receptors, cytoskeletal components such as actin, and the dystrophin glycoprotein complex, organizing their subcellular localization—especially at the membrane—via its PDZ domain[1][2][7]. It is involved in the proper localization and assembly of ion channels and signaling complexes. Disruption or absence of SNTG2 has been linked to neurological and muscular disorders, including muscular dystrophy (notably Duchenne muscular dystrophy), as well as neurodevelopmental and psychiatric diseases such as autism, bipolar disorder, and schizophrenia[1][2]. There are currently no approved drugs that specifically target SNTG2, and it is not classified as a canonical drug target such as a receptor, enzyme, transporter, or ion channel[2][7].

Other names

Gamma-2-syntrophinSNTG2G2SYNSYN5syntrophin-5