Target intelligence / Profile preview

Gamma-aminobutyric acid (GABA)

Target: GABA
Molecular classification: Amino acid, Neurotransmitter

Overview

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the mammalian central nervous system. It plays a critical role in reducing neuronal excitability throughout the nervous system. GABA mediates neuronal inhibition by binding to postsynaptic GABA receptors, leading to the influx of chloride ions into the neuron, hyperpolarizing the membrane, and reducing the likelihood of an action potential.

Other names: γ-aminobutyric acid4-aminobutanoic acid

Mechanism of action

N/A

Biological functions

Inhibitory neurotransmissionRegulation of cortical excitabilityAnxiety reductionStress management

Disease associations

Anxiety disordersEpilepsySleep disordersNeurological disorders

Interacting drugs

Barbiturates

4 more in the full profile.

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