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Target intelligence / Profile preview
Gamma-aminobutyric acid A receptor alpha-2 subunit (GABRA2)
- Target
- GABRA2
- Molecular classification
- Ligand-gated ion channel, Receptor, GABA-A receptor subunit
01
Overview
The gamma-aminobutyric acid A receptor alpha-2 subunit (GABRA2) is a protein encoded by the GABRA2 gene in humans. It forms part of the GABA-A receptor, which is a ligand-gated chloride channel activated by gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain. The GABA-A receptors are pentameric complexes typically composed of two alpha, two beta, and one gamma subunit; GABRA2 represents one of six possible alpha subunits. Activation by GABA leads to hyperpolarization of neuronal membranes, inhibiting neuronal firing. GABRA2 plays key roles in emotional regulation and behavioral control and has been linked to conditions such as alcoholism, anxiety disorders, and epilepsy.
- Other names
- Gamma-aminobutyric acid type A receptor alpha 2Gabra-2GABA(A) receptor subunit alpha‑₂
02
Mechanism of action
Positive allosteric modulation of GABA-A receptor, leading to increased chloride ion conductance and neuronal hyperpolarization.
03
Biological functions
Inhibitory neurotransmissionChloride ion transportEmotional regulationBehavioral control
04
Disease associations
AlcoholismAnxiety disordersEpilepsy
05
Safety considerations
Potential for tolerance and dependence with benzodiazepinesSide effects associated with GABAergic drugs, such as sedation and cognitive impairment
06
Interacting drugs
Alprazolam
3 more in the full profile.
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