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Target intelligence / Profile preview
Gamma-aminobutyric acid A receptor alpha 5 subunit (GABRA5)
- Target
- GABRA5
- Molecular classification
- Ligand-gated ion channel, GABA receptor subunit, Receptor
01
Overview
The gamma-aminobutyric acid (GABA) A receptor alpha 5 subunit (GABRA5) is a subunit of the GABA(A) receptor, the primary mediator of fast inhibitory neurotransmission in the mammalian central nervous system. α5-containing GABA(A) receptors are predominantly found extrasynaptically in the hippocampus and contribute significantly to tonic inhibition. Activated by GABA, these receptors open their chloride channel pore, allowing Cl⁻ ions to flow into neurons, hyperpolarizing the cell membrane and reducing neuronal excitability. Altered function or expression of α5-containing GABA(A) receptors has been implicated in various neurological conditions, making it a target for nootropics and cognitive disorder therapies.
02
Mechanism of action
Allosteric modulation of chloride channel opening probability
03
Biological functions
Inhibitory neurotransmissionRegulation of neuronal excitabilityLearning and memory processesTonic inhibition
04
Disease associations
Down syndrome-related cognitive deficitsSchizophrenia spectrum disordersEpilepsyAlzheimer's disease
05
Safety considerations
Cognitive impairmentAnterograde amnesia
06
Interacting drugs
Benzodiazepines
5 more in the full profile.
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