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Target intelligence / Profile preview
Gamma-aminobutyric acid A receptor subunit alpha-2 (GABRA2)
- Target
- GABRA2
- Molecular classification
- Ligand-gated ion channel, Receptor, GABA-A receptor subunit
01
Overview
Gamma-aminobutyric acid A receptor subunit alpha-2 (GABRA2) is a protein subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the brain. GABRA2 contributes to the formation of pentameric GABA-A receptors, influencing their pharmacology and physiological function. Alterations in GABRA2 expression or function have been implicated in neuropsychiatric disorders, including alcohol dependence and anxiety.
- Other names
- GABA-A receptor subunit alpha-2
02
Mechanism of action
Positive allosteric modulation of GABA-A receptor activity.
03
Biological functions
Inhibitory neurotransmissionChloride ion conductanceModulation of neuronal excitability
04
Disease associations
Alcohol dependence/addiction susceptibilityAnxiety disorders
05
Interacting drugs
Benzodiazepines
1 more in the full profile.
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