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Target intelligence / Profile preview
Gamma-aminobutyric acid-gated chloride channel (GABA_A receptor)
- Target
- GABA_A receptor
- Molecular classification
- Ligand-gated ion channel, Ionotropic receptor
01
Overview
The GABA_A receptor is a ligand-gated chloride channel that mediates fast synaptic inhibition in the central nervous system. It is a pentameric protein composed of various subunits, resulting in diverse receptor isoforms with distinct pharmacological properties. The receptor is a major target for anxiolytic, sedative, and anticonvulsant drugs.
- Other names
- GABA-A receptorGABA(A) receptor
02
Mechanism of action
Binding to the GABA_A receptor enhances chloride ion conductance, leading to hyperpolarization and inhibition of neuronal activity.
03
Biological functions
Inhibitory neurotransmissionChloride ion conductanceRegulation of neuronal excitability
04
Disease associations
EpilepsyAnxiety disordersInsomniaAlcoholismSchizophreniaNeurodevelopmental disorders
05
Safety considerations
SedationRespiratory depressionToleranceDependenceWithdrawal symptomsCognitive impairment
06
Interacting drugs
Benzodiazepines
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