Gamma-Aminobutyric Acid-Mediated Inhibition (GABAergic Inhibition)

Gamma-aminobutyric acid (GABA)-mediated inhibition is the primary mechanism by which neuronal excitability is reduced in the central nervous system. It involves the action of GABA on GABAA and GABAB receptors. GABAA receptors are ionotropic receptors that mediate fast inhibition through chloride ion influx, while GABAB receptors are metabotropic receptors that mediate slower, more prolonged inhibition through potassium channel activation and calcium channel inhibition. This inhibitory process is crucial for maintaining the balance between excitation and inhibition in the brain, preventing hyperexcitability, and regulating various neurological functions.

Other names

GABA inhibitionGABAergic neurotransmissionInhibitory neurotransmission (GABA)GABA-mediated neurotransmission

Enhancement of GABAergic neurotransmission via increased chloride ion conductance (GABAA receptors) or activation of potassium channels and inhibition of calcium channels (GABAB receptors).