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Target intelligence / Profile preview
Gamma-aminobutyric Acid Receptor (Invertebrate) (iGABAR)
- Target
- iGABAR
- Molecular classification
- Ligand-gated ion channel, Ionotropic receptor
01
Overview
The gamma-aminobutyric acid (GABA) receptor in invertebrates is a ligand-gated ion channel that mediates the effects of the neurotransmitter GABA. It is a pentameric transmembrane protein, primarily permeable to chloride ions, and responsible for inhibitory neurotransmission. Invertebrate GABA receptors exhibit significant sequence and pharmacological diversity compared to their vertebrate counterparts. They are important targets for insecticides and represent valuable models for evolutionary neurobiology.
- Other names
- Invertebrate GABA receptorGABA receptor (Invertebrates)
02
Mechanism of action
Chloride channel activation leading to neuronal hyperpolarization and inhibition.
03
Biological functions
Synaptic inhibitionChloride ion transportNeurotransmissionMotor program selection and coordinationNeuromodulation
04
Safety considerations
Potential for off-target effects with broad-spectrum GABAergic agents.Development of resistance in pest populations.
05
Interacting drugs
Picrotoxinin (PTX)
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