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Target intelligence / Profile preview
Gamma Aminobutyric Acid Receptor A (GABAA receptor)
- Target
- GABAA receptor
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor
01
Overview
The GABAA receptor is a major inhibitory neurotransmitter receptor in the mammalian central nervous system. It is an ionotropic, ligand-gated chloride channel activated by γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. Activation of this receptor typically results in neuronal hyperpolarization and inhibition of action potential firing.
- Other names
- GABA-A receptorGABAA
02
Mechanism of action
Binding of GABA opens a chloride channel, leading to hyperpolarization and reduced neuronal excitability. Allosteric modulators like benzodiazepines and barbiturates enhance this effect.
03
Biological functions
NeurotransmissionInhibition of neuronal excitabilityRegulation of chloride ion flux
04
Disease associations
EpilepsySchizophreniaAutism spectrum disordersAnxiety disordersPostpartum depressionAlzheimer’s diseaseStroke recovery deficits
05
Safety considerations
SedationRespiratory depressionToleranceDependenceAbuse potential
06
Interacting drugs
GABA
4 more in the full profile.
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