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Target intelligence / Profile preview
Gamma-aminobutyric acid receptor subunit alpha 2 (GABRA2)
- Target
- GABRA2
- Molecular classification
- Ligand-gated ion channel, Receptor, GABA-A receptor subunit
01
Overview
Gamma-aminobutyric acid receptor subunit alpha 2 (GABRA2) is a protein that forms part of the GABA-A receptor, a ligand-gated chloride channel activated by GABA, the primary inhibitory neurotransmitter in the mammalian brain. GABRA2-containing receptors are primarily found in the hippocampus and forebrain, mediating inhibitory neurotransmission and playing a role in alcohol dependence, anxiety, and potentially epilepsy.
- Other names
- Gamma aminobutyric acid A receptor, alpha 2Gabra‐two
02
Mechanism of action
Positive allosteric modulation of GABA-A receptor, increasing chloride ion conductance
03
Biological functions
Inhibitory neurotransmissionChloride ion conductanceSynaptogenesis
04
Disease associations
Alcohol dependenceAnxiety disordersEpilepsyDevelopmental disorders
05
Safety considerations
Potential for tolerance and dependence with benzodiazepinesRisk of seizures upon withdrawal of benzodiazepines
06
Interacting drugs
Benzodiazepines
1 more in the full profile.
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